7-Ethyl-10-hydroxycamptothecin CAS 86639-52-3

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US $12-14 / Gram | 100 Gram/Grams (Min. Order)
Supply Ability:
10 Kilogram/Kilograms per Month
Port:
Shanghai or Hangzhou or Beijing etc
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Overview
Quick Details
CAS No.:
86639-52-3
Other Names:
7-Ethyl-10-hydroxycamptothecin
MF:
C22H20N2O5
EINECS No.:
NA
Place of Origin:
Zhejiang, China (Mainland)
Type:
Pharmaceutical Intermediates, Syntheses Material Intermediates
Purity:
95.0%min
Brand Name:
afine
Model Number:
AFI0135
Application:
Pharmaceutical Intermediates
Appearance:
light-yellow solid
Price:
Negotiable & depends on quantity
MOQ:
According to regular packing
COA & Document:
Please send us inquiry
Packaging & Delivery
Packaging Details
According to regular packing.
Delivery Time
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7-Ethyl-10-hydroxycamptothecin CAS NO.:86639-52-3, Pharmaceutical Intermediates

 

Appearance:
light-yellow solid
Molecular Weight:
392.40
Density:
1.51 g/cm3
Boiling Point:
810.3 °C at 760 mmHg
Melting Point:
217 °C
Flash Point:
443.8 °C
Storage Temperature:
?20°C
Refractive index:
21.5 ° (C=0.2, THF)
Biological Activity:
Active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
Usage:

A metabolite of Irinotecan, a DNA topoisomerase inhibitor