7-Ethyl-10-hydroxycamptothecin CAS NO.:86639-52-3, Pharmaceutical Intermediates
810.3 °C at 760 mmHg
21.5 ° (C=0.2, THF)
Active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
A metabolite of Irinotecan, a DNA topoisomerase inhibitor